Introduction about Astronauts and space:
For human beings, going to space may seem the most exciting thing, but our bodies do not enjoy it that much. Moving out of the earth’s atmosphere means leaving the protective blanket that saves us from ultraviolet radiation among other harmful stuff out there in space for astronauts. The radiation, as you may guess, causes damage to the human DNA, which could lead to cancer in humans and animals as well. Thankfully, our cells do have natural mechanisms in place to repair the damage. They deploy different strategies depending upon the type of damage.
DNA damage can occur as a result of environmental causes such as UV radiation exposure. Ionizing radiation (heat or light that steals electrons from atoms) that permeates space makes that risk larger outside of Earth’s shielding atmosphere.
How Astronauts got success edit genes in space:
Researchers have developed and successfully demonstrated a novel method for studying how cells repair damaged DNA in space. Sarah Stahl-Rommel of Genes in Space and colleagues present the new technique in the open-access journal PLOS ONE on June 30, 2021.
CRISPR/Cas9 genome editing technology is used to induce precise DNA damage in the new procedure, which was tested onboard the International Space Station.Scientists will be able to examine the repair mechanisms in greater depth than they could with radiation, which is more difficult to use in specific ways, said reports. .
In a spaceflight setting, the yeast cell experiment was the first time an organism’s genome was altered, DNA was repaired, and then sequenced. Future studies could improve on these methods to better imitate complex DNA damage, potentially leading to new ways to protect astronauts as well as inquiries into other long-term space exposure and exploration said reports.
Future research could refine the new method to better mimic the complex DNA damage caused by ionizing radiation. The technique could also serve as a foundation for investigations into numerous other molecular biology topics related to long-term space exposure and exploration.
The researchers carried out the experiments utilizing the brand new technique on yeast cells. This was the primary time gene-editing was taking place in house.
Analysis of Technology:
Earlier analysis has discovered that how cells decide a selected restore technique could be influenced by the microgravity situations in house. Scientists are involved that DNA repairs influenced by microgravity situations will not be sufficient, and may result in dangerous penalties.
In accordance with Sebastian Kraves, who’s the senior writer of the analysis, the analysis integrates gene-editing methods within the excessive surroundings to “functionally full biotechnology circulate” that may be utilized for finding out different elementary cell processes as effectively. “These developments fill this crew with hope in humanity’s renewed quest to discover and inhabit the huge expanse of house,” mentioned Kraves in an announcement by PLOS. The study was revealed in PLOS ONE on June 30,2021.